The Red Devils host Kazakhstani outfit Astana at Old Trafford as Ole Gunnar Solskjaer looks to lead the club to European glory as a coach having already helped do so as a player in Barcelona in 1999.
Under the Norwegian, United reached the Champions League quarter-final stage last season only to be well beaten by Barcelona in the last eight.
With the competition less fierce in the Europa League, United will be regarded as one of the favourites, but Solskjaer is expected to name mix-and-match teams for at least the group stage.
“It’s a chance for some other players to get some minutes. We have a game every three or four days now so we’ll see the use of the squad tomorrow,” he said, speaking on Wednesday.
“It’s not just about enjoying yourself, it’s about getting results. But if you don’t throw them in, you don’t know what you’ve got.
“In the Europa League you meet different types of teams and cultures. It’s important we win our home games, especially with two of our away games on astroturf.
“I think all the boys watched the Premier League games, the top games, watch other teams win trophies. I think they will want to get there [Champions League], and we want to get there. The Europa League is a pathway to get there.”
What time does Man Utd vs Astana kick-off?
The Europa League clash kicks off at 8pm BST.
What TV channel is Man Utd vs Astana on?
Live television coverage can be found on BT Sport 2 throughout the UK.
Their Man Utd vs Astana programme is scheduled to start at 8pm, but it is likely build-up to the match will be shown after Eintracht Frankfurt’s clash with Arsenal, which precedes the Old Trafford tie.
Can I live stream Man Utd vs Astana?
Live streaming is available via the BT Sport app for existing customers.
Fans can also stream the action through the BT Sport website.
EE mobile customers, though, can enjoy three months of free access to the BT Sport app.
Simply text SPORT to 150 to receive the offer, which can be cancelled at any time.