The Gunners risk falling further behind in the race for top four if they lose against the Foxes.
Meanwhile, Leicester want to cement their position in the Champions League places, as Brendan Rodgers aims to upset the Premier League’s ‘big six’.
Arsenal boss Unai Emery will have a number of crucial decisions to make, including whether to hand Mesut Ozil his third league start of the season.
Emery will inevitably continue with Bernd Leno in goal against Leicester.
Calum Chambers is likely to be preferred at right-back to makeshift wing-back Ainsley Maitland-Niles.
David Luiz and Sokratis face a challenge from Rob Holding for a place in the starting line-up.
But Emery is likely to opt for experience in a tough away match, with the usual duo appearing at centre-back.
Kieran Tierney has started the last two league matches for the Gunners, and is expected to continue.
In midfield, Emery will be forced into a shake-up of his usual trio.
Dani Ceballos picked up a hamstring injury against Vitoria in midweek, whereas Granit Xhaka still isn’t ready to return to action after his outburst against the Arsenal fans.
That means the manager may consider playing both Matteo Guendouzi and Lucas Torreira as a holding midfield pairing.
Mesut Ozil retains his place in the side after starting against Wolves last weekend, and he’ll play at the top of a midfield three.
Arsenal’s potent strike force will continue against Leicester, with Nicolas Pepe expected to start on the right-hand side.
New club captain Pierre-Emerick Aubameyang will feed off the left-wing.
That leaves striker Alexandre Lacazette to lead the line, looking for only his third goal of the season after missing four matches through injury in September.